Products + Services
High-Quality, Human-Relevant Cells for High-Throughput Screening and Complex Multicellular Models
Why choose Cytochroma's Cells?
Human relevance:
Derived from genetically diverse iPSC lines
Consistency:
Controlled, animal-free manufacturing*
Scalability:
Large-batch sizes for HTS and complex models
Customisation:
Tailor models with single or multi-cell type co-cultures
*We avoid animal products wherever possible, the majority of our processes are animal free.
Products
Hepatocytes
Mature, Polarized & Functional
Cytochroma's hepatocytes reflect adult physiology, produce albumin Cytochrome P450 enzymes and are drug inducible. They mimic the liver’s highly organised structure, making drug transporter and efflux studies more physiologically predictive.
All hepatocytes are derived from our unique iPS library containing distinct genetic backgrounds with commonly occurring polymorphisms in key cytochrome P450 genes.
Male and female models can be used to understand gender specific effects and detect toxicity in a global population ahead of clinical trials.
Polarized bile canaliculi structures
Lipid-loading capability for steatosis models
Ideal for 2D and 3D liver systems, high-throughput toxicology, and metabolic disease studies
Batch-to-batch consistency, animal-free, scalable
Available from six healthy donor backgrounds.
Perfect for:
DILI screening, drug metabolism assays, and modelling MAFLD, MASH, fibrosis, inflammation and steatosis.
Endothelial Cells
Predict vascular toxicity, barrier disruption, and inflammatory responses
Endothelial cells are involved in multiple processes including blood flow, vascular permeability or angiogenesis. Cytochroma can manufacture endothelial cells from the iPSC line that best fits your project via a controlled and scalable process. Custom assays can be developed with this fully functional cell model to screen drug-induced effects on endothelial barrier permeability or 3D capillary tube formation.
Expression of vascular markers (CD31, VE-Cadherin, vWF)
Form tight junctions and capillary-like networks
Respond to inflammatory stimuli (e.g., TNFα)
Support complex co-culture systems
Available from six healthy donor backgrounds.
Perfect for:
Liver-on-a-Chip, vascularized spheroids, fibrosis progression models
Macrophages
Model Liver Inflammation with iPSC-Derived Macrophages
Cytochromas macrophages mimic primary human macrophages, offering a scalable platform to study inflammation, immune responses, and tissue remodeling. They can be integrated into complex tissue models to assess immune-driven toxicity and improve preclinical relevance.
Express CD206, CD14, CD11b, and CD86
Secrete inflammatory cytokines (TNFα, IL-1β, IL-6) in response to stimuli
Functional phagocytosis assays
Engineered for use in multi-cellular liver models
Available from three healthy donor backgrounds
Perfect for:
MASH inflammation models, immune-mediated liver injury studies, immunotoxicology
Cardiac Fibroblasts
Build complex Cardiac Models with iPSC Cardiac Fibroblasts
Cardiac fibroblasts play a role in regulating normal myocardial function, and in the myocardial remodelling that occurs with heart disease.
Cardiac fibroblasts are highly pure with low variability between lots, ideal for a variety of purposes. From co-culture with Cardiomyocytes for further maturation, aiding in the formation of engineered heart tissue to disease modelling, these versatile cells can accelerate your drug discovery research, high-throughput screening and toxicity assessments. Use on their own or with our isogenic iPSC-derived heart cell types to create complete heart models.
Ready-to-use post-thaw for streamlined workflows
Co-culture with Cytochroma’s Cardiomyocytes to model human cardiac tissue
Support applications in disease research, drug discovery, safety testing, and regenerative medicine
Consistent performance ensured by rigorous quality control
Available from six healthy donor backgrounds
Perfect for:
Engineered heart tissue models, cardiotoxicity screening, cardiac fibrosis
Ventricular Cardiomyocytes
Advance Cardiac Research with iPSC-Derived Ventricular Cardiomyocytes
Cytochroma’s ventricular cardiomyocytes are functional, contractile cells that mimic native heart tissue and are ready-to-use post-thaw for seamless integration into cardiac assays. Derived from six healthy donors and rigorously quality-controlled, these cells offer consistency and reliability across batches.
Whether used alone or in co-culture with cardiac fibroblasts, they support a wide range of applications—from engineered heart tissue formation and cardiomyocyte maturation to disease modelling and safety pharmacology.
Accelerate your drug discovery, cardiotoxicity screening with these physiologically relevant, human-based cardiac models.
Key Features
Ready-to-use post-thaw for streamlined workflows
Demonstrate spontaneous contractile activity and electrophysiological functionality
Co-culture compatible with iPSC-derived cardiac fibroblasts and endothelial cells
Ideal for cardiotoxicity screening, disease modelling, and tissue engineering
Batch-to-batch consistency ensured by rigorous quality control
Available from six diverse, healthy donor backgrounds to support population-relevant studies
Perfect for:
Engineered heart tissue models, cardiotoxicity screening, cardiac fibrosis research, disease modelling and drug discovery
Services
In Vitro MAFLD/MASH Disease Models
Model Human Disease Progression. De-Risk Early Decisions.
Our semi-automated, animal-free hepatocyte systems reliably recapitulate the progression from healthy liver to steatosis, inflammation, and fibrosis. Utilizing disease induction protocols and diverse genetic backgrounds, we enable detailed compound screening in a clinically relevant context — with lower variability and higher biological accuracy than primary cells.
Key Benefits:
Human-Accurate Models: Study disease initiation, progression, and regression with confidence.
Quantitative Readouts: Measure lipid droplet size, number, and hepatocyte health.
Faster Go/No-Go Decisions: Rapid turnaround to prioritise candidates ahead of in vivo studies.
Steatosis, inflammation and fibrosis readouts available.
Safety/Toxicity
Predict and Prevent DILI Early with Cytochroma’s iPSC Liver Models
Drug-induced liver injury (DILI) remains a leading cause of drug development failure. Early, reliable detection is critical to reduce attrition and protect valuable R&D investment.
Cytochroma’s DILI Screening Services deliver:
Human-Relevant Assays: Functional, mature iPSC-derived hepatocyte models
Genetically Diverse Library: Capture CYP450 polymorphisms seen across global populations
Qualified, Predictive Platforms: Designed to flag hepatotoxicity before clinical trials
Partner with Cytochroma to confidently advance safer, more successful therapies.
Phenotypic Screening Services
Visualise and Quantify Cellular Response at Scale
Our high-content phenotypic imaging platforms provide rapid, cost-effective insight into compound effects on cell health, morphology, and function. Cytochroma supports hit identification, lead optimization, and mechanism-of-action studies, delivering high-quality, actionable data at every stage of development.
Applications:
Primary and secondary screening
Predictive toxicology
Complex cellular system modeling
Custom R&D and iPSC Cell manufacture
Personalized, physiologically relevant cell models are essential to de-risk drug discovery and advance cell therapy applications
Cytochroma’s custom manufacturing services ensure your models are tailored, scalable, and predictive for your unique research needs.
Client-Dedicated Batches:
Select cell models manufactured as dedicated batches for your project, ensuring consistency and traceability.Flexible Formats and Quantities:
Models produced in a variety of formats (2D, 3D, organoid) and scalable quantities to fit high-throughput or niche requirements.Customisable Model Parameters:
Opportunity to customise critical cell model parameters-including differentiation protocols, medium, and supplements-for your drug discovery or cell therapy applications.Pre-Delivery Qualification:
Cell models assayed in-house prior to delivery, qualifying performance for your specific application.Universal iPSC Line Compatibility:
Manufacturing process applicable to any iPSC line, enabling use of custom or disease-specific backgrounds.Bespoke Service:
Quantities and formats made to order, with end-to-end support from protocol design to final delivery.
Partner with Cytochroma to advance your research with robust, human-relevant models that reflect the complexity and diversity of patient populations.
powerful data drives discovery
Wet AI™
large-scale wet-lab experiments and machine learning
Though large-scale wet-lab experiments and machine learning Cytochroma is building data sets that harnesses the complexity and diversity of human biology, driving faster more advanced drug discovery.
Rapid, Iterative Discovery
Traditional biology is slow and expensive. Wet AI™ creates automated feedback loops between experiments and AI models, massively accelerating the pace of discovery.
Better, Human-Relevant Data
Wet AI™ generates bespoke experimental data using Cytochroma's diverse iPS derived cells improving biological relevance over generic or outdated datasets.
Target & Phenotype Discovery at Scale
By training models on live, diverse, and disease-relevant data, Wet AI™ helps uncover novel drug targets, biomarkers, and phenotypic responses that would otherwise be missed.
De-Risks Drug Development
Wet AI™ allows early validation of mechanisms and compounds in predictive systems, reducing downstream clinical failures — a multi-billion-dollar problem in pharma.
Partner with Cytochroma to advance your drug discovery journey.
For any inquiries or to explore your vision further, we invite you to contact our professional team using the details provided below.