Cell models and scientific support for more representative preclinical research.
SCIENTIFIC SERVICES
Model Human Disease Progression. De-Risk Early Decisions
In Vitro MAFLD/MASH Disease Models
Our semi-automated, animal-free hepatocyte systems reliably recapitulate the progression from healthy liver to steatosis, inflammation, and fibrosis. Utilizing disease induction protocols and diverse genetic backgrounds, we enable detailed compound screening in a clinically relevant context — with lower variability and higher biological accuracy than primary cells.
Key Benefits:
Human-Accurate Models: Study disease initiation, progression, and regression with confidence.
Quantitative Readouts: Measure lipid droplet size, number, and hepatocyte health.
Faster Go/No-Go Decisions: Rapid turnaround to prioritise candidates ahead of in vivo studies.
Steatosis, inflammation and fibrosis readouts available.
Predict and Prevent DILI Early with Cytochroma’s iPSC Liver Models
Safety and Toxicity
Drug-induced liver injury (DILI) remains a leading cause of drug development failure. Early, reliable detection is critical to reduce attrition and protect valuable R&D investment.
Cytochroma’s DILI Screening Services deliver:
Human-Relevant Assays: Functional, mature iPSC-derived hepatocyte models
Genetically Diverse Library: Capture CYP450 polymorphisms seen across global populations
Qualified, Predictive Platforms: Designed to flag hepatotoxicity before clinical trials
Partner with Cytochroma to confidently advance safer, more successful therapies.
Visualise and Quantify Cellular Response at Scale
Phenotypic Screening Services
Our high-content phenotypic imaging platforms provide rapid, cost-effective insight into compound effects on cell health, morphology, and function. Cytochroma supports hit identification, lead optimization, and mechanism-of-action studies, delivering high-quality, actionable data at every stage of development.
Applications:
Primary and secondary screening
Predictive toxicology
Complex cellular system modeling
Cant find it? we'll build it!
Custom R&D and Cell manufacture
Cytochroma’s custom manufacturing services ensure your models are tailored, scalable, and predictive for your unique research needs.
Client-Dedicated Batches:
Select cell models manufactured as dedicated batches for your project, ensuring consistency and traceability.Flexible Formats and Quantities:
Models produced in a variety of formats (2D, 3D, organoid) and scalable quantities to fit high-throughput or niche requirements.Customisable Model Parameters:
Opportunity to customise critical cell model parameters-including differentiation protocols, medium, and supplements-for your drug discovery or cell therapy applications.Pre-Delivery Qualification:
Cell models assayed in-house prior to delivery, qualifying performance for your specific application.Universal iPSC Line Compatibility:
Manufacturing process applicable to any iPSC line, enabling use of custom or disease-specific backgrounds.Bespoke Service:
Quantities and formats made to order, with end-to-end support from protocol design to final delivery.
Partner with Cytochroma to advance your research with robust, human-relevant models that reflect the complexity and diversity of patient populations.
For any inquiries or to explore your vision further, we invite you to contact our professional team using the details provided below.
Location
Cytochroma Limited, Roslin Innovation Centre, Charnock Bradley Building, Easter Bush Campus, Edinburgh, EH25 9RG, UK
Phone
+44(0) 131 6519 715